Distinct clinical, serological, and sonographic characteristics of hashimoto's thyroiditis based with and without IgG4-positive plasma cells. (Article, 2010) [Fuller Libraries]
skip to content
Distinct clinical, serological, and sonographic characteristics of hashimoto's thyroiditis based with and without IgG4-positive plasma cells.
ClosePreview this item

Distinct clinical, serological, and sonographic characteristics of hashimoto's thyroiditis based with and without IgG4-positive plasma cells.

Author: Y Li Affiliation: Department of Human Pathology, Wakayama Medical University, Kimiidera 811-1, Wakayama, 641-8509, Japan.E NishiharaM HirokawaE TaniguchiA MiyauchiAll authors
Edition/Format: Article Article : English
Publication:The Journal of clinical endocrinology and metabolism, 2010 Mar; 95(3): 1309-17
  Peer-reviewed
Other Databases: WorldCatWorldCatWorldCat
Summary:
CONTEXT: IgG4-related sclerosing disease is a new syndrome characterized by high serum IgG4 levels and increased IgG4-positive plasma cells in the involved organs. Recently the first description was made by our group of a subsection of Hashimoto's autoimmune thyroiditis (HT) patients showing indistinguishable histopathological features with IgG4-related sclerosing disease, which was termed as IgG4 thyroiditis.  Read more...
You are not connected to the Fuller Libraries network. Access to online content and services may require you to authenticate with your library. Remote Access Login
Getting this item's online copy... Getting this item's online copy...

Find a copy in the library

Getting this item's location and availability... Getting this item's location and availability...

WorldCat

Find it in libraries globally
Worldwide libraries own this item

Details

Document Type: Article
All Authors / Contributors: Y Li Affiliation: Department of Human Pathology, Wakayama Medical University, Kimiidera 811-1, Wakayama, 641-8509, Japan.; E Nishihara; M Hirokawa; E Taniguchi; A Miyauchi; K Kakudo
ISSN:0021-972X
DOI: 10.1210/jc.2009-1794
Language Note: English
Unique Identifier: 604864537
Awards:

Abstract:

CONTEXT: IgG4-related sclerosing disease is a new syndrome characterized by high serum IgG4 levels and increased IgG4-positive plasma cells in the involved organs. Recently the first description was made by our group of a subsection of Hashimoto's autoimmune thyroiditis (HT) patients showing indistinguishable histopathological features with IgG4-related sclerosing disease, which was termed as IgG4 thyroiditis. OBJECTIVE: The objective of the study was analysis of the immunophenotypic features of IgG4 in 70 cases of HT patients and to clarify the histopathological and clinical characteristics of the patients with IgG4 thyroiditis. DESIGN: Thyroid tissue samples were obtained from 70 patients with HT who were treated surgically. Quantitative analyses of the expression of IgG4 and IgG were performed. Statistical analyses of clinical and histopathological parameters were also conducted. RESULTS: On the basis of immunohistochemistry of IgG4 and IgG4/IgG ratio, the 70 patients with HT were divided into two groups: IgG4 thyroiditis (19 cases) and non-IgG4 thyroiditis (51 cases). Histopathologically, IgG4 thyroiditis showed higher grade of stromal fibrosis, lymphoplasmacytic infiltration, and follicular cell degeneration than non-IgG4 thyroiditis. Moreover, these two groups were also demonstrated to be related with different clinical features, with IgG4 thyroiditis associated more with male gender, rapid progress, subclinical hypothyroidism, more diffuse low echogenicity, and higher level of circulating antibodies. CONCLUSIONS: From both clinical and histopathological aspects, IgG4 thyroiditis and non-IgG4 thyroiditis were demonstrated to be distinct entities. Measuring serum IgG4 concentration provides a useful method of distinguishing IgG4 thyroiditis from non-IgG4 thyroiditis.
Retrieving notes about this item Retrieving notes about this item

Reviews

User-contributed reviews

Tags

All user tags (25)

View most popular tags as: tag list | tag cloud

  • 15  (by 1 person)
  • 16  (by 1 person)
  • 17  (by 1 person)
  • 18  (by 1 person)
  • 19  (by 1 person)
  • 20  (by 1 person)
  • 21  (by 1 person)
  • 22  (by 1 person)
  • 23  (by 1 person)
  • 24  (by 1 person)
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.