Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status (Article, 2008) [Fuller Libraries]
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Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status
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Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status

Author: L -D Xie Affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China; Y Gao Affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China; M -R Li Affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China; G -Z Lu Affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China; X -H Guo Affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China
Edition/Format: Article Article : English
Publication:Clinical & Experimental Immunology, v154 n2 (November 2008): 172-176
  Peer-reviewed
Other Databases: WorldCatAcademic Search CompleteWorldCatWorldCatWorldCat
Summary:
The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Anti-thyroid peroxidase antibody (TPOAb), a diagnostic hallmark of HT, is principally of the immunoglobulin G (IgG) isotype, and it appears to be a response to thyroid injury. The aim of our study was to evaluate the distribution of IgG subclasses of TPOAb in sera from patients with HT with different thyroid functional status.  Read more...
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Document Type: Article
All Authors / Contributors: L -D Xie Affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China; Y Gao Affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China; M -R Li Affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China; G -Z Lu Affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China; X -H Guo Affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China
ISSN:0009-9104
DOI: 10.1111/j.1365-2249.2008.03756.x
Language Note: English
Unique Identifier: 5154970502
Notes: Y. Gao, Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.
E-mail: bjgaoying@yahoo.com
Accepted for publication 15 July 2008
Number of Tables: 4
Number of References: 26
Number of Words: 3309
Awards:
Other Titles: TPOAb IgG subclass distribution in sera from patients with HT
Responsibility: L.-D. Xie et al.

Abstract:

The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Anti-thyroid peroxidase antibody (TPOAb), a diagnostic hallmark of HT, is principally of the immunoglobulin G (IgG) isotype, and it appears to be a response to thyroid injury. The aim of our study was to evaluate the distribution of IgG subclasses of TPOAb in sera from patients with HT with different thyroid functional status. Sera from 168 patients with newly diagnosed HT were collected and divided into three groups according to thyroid function: patients with hypothyroidism (n = 66), subclinical hypothyroidism (n = 60) and euthyroidism (n = 42). Antigen-specific enzyme-linked immunosorbent assay was used to detect the distribution of TPOAb IgG subclasses. The prevalence of TPOAb IgG subclasses in all patients’ sera with HT was IgG1 70·2%, IgG2 35·1%, IgG3 19·6% and IgG4 66·1% respectively. The prevalence of IgG2 in sera from patients with hypothyroidism (51·5%) was significantly higher than that of subclinical hypothyroidism (33·3%) (P < 0·05), and the latter was also significantly higher than that of euthyroidism (11·9%) (P < 0·05). The positive percentage of IgG2 subclass in sera from patients with hypothyroidism and subclinical hypothyroidism was significantly higher than that of euthyroidism (P < 0·05), the prevalence and positive percentage of IgG4 subclass in sera from patients with hypothyroidism and subclinical hypothyroidism was significantly higher than that of euthyroidism respectively (P < 0·05). The predominant TPOAb IgG subclasses in sera from patients with HT were IgG1 and IgG4. Patients with high levels of TPOAb IgG2, IgG4 subclasses might be at high risk of developing overt hypothyroidism.
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